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Taking it with food slows down how fast your body absorbs the medicine. Taking a beta blocker can make you feel more tired or dizzy, especially in the first few days. There is no specific recommendation regarding the time of day. Don’t drink more than one glass (300 mL) a day. Take Bystolic exactly as prescribed by your doctor. For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg BYSTOLIC can be taken with or without food. Do not take more or less of it or take it more often than prescribed by your healthcare provider. Nebivolol is highly protein-bound, mostly to albumin at 98%, independent of its concentrations. Nebivolol and ethanol may have additive effects in lowering your blood pressure. 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